Connectivity hypothsis

Connectivity has been implicated as a central abnormality in schizophrenia.

Definitive pathophysiologica basis for abnromal connectivity remeains elusive.

Only until recently whit matter, ie oligodendroglia and myelin, in the pathogenesis of schizophrenia. The cellular and molecular abnormalities found in Sz brain.

Neuronal connectivity affected profoundly by
- myelination
- factors that affect myelination (oligodendroglia function)
- quality of myelin deposition (affected by oligodendroglia function)
- synaptic transmission (also affected by oligodendroglia function)



Davis et al. 2003 White Matter Changes in Sz. Evidence for Myelin-related dysfunction. Arch Gen Psyc 2003:60:443-456.